Alzheimer's Disease: The Role Of Genetic Factors
Unfortunately, today there has still not been found any cure from Alzheimer's disease. But despite this, the doctors can prevent its occurrence using various preventive measures knowing the factors that trigger its development. Without a doubt, trying to deal effectively with aging or genetic predisposition to the disease, you will not succeed, but by controlling the level of cholesterol in the blood, following the proper diet and exerciseing regularly, it is very like;y that you will maintain a high level of brain activity.
The main factors that trigger Alzheimer's disease
- Age .It is believed that every second person at the age of 85 suffers from this disease.
- Genetic predisposition. Genetic predisposition common for a rare form of Alzheimer's disease, which begins to progress in a fairly young age, when the presom is about 45-50 years.
- Traumatic brain injury. Injury that resulted in the loss of consciousness increases the risk of developing the disease significantly.
- Diabetes and metabolic disorders associated with it.
- Diseases of the heart and blood vessels can cause progression of dementia associated with Alzheimer's disease.
The role of genetic factors in the development of Alzheimer's disease
A few decades ago scientists have mentioned a proven fact that a genetic predisposition to the disease is the most significant risk factor. Numerous experiments have identified several genes, mutations of which are able to give impetus to the development of Alzheimer's disease at a young age (to the age of 50).
Thus, today several major genes the mutations of which cause the disease are revealed:
- Presenilin1 gene. It is the most common mutation and is observed during an early form of Alzheimer's disease. This is the most aggressive form of the disease, which may begin to appear as early as at the age of 35. It should be noted that the mutation of this gene was found in each ethnic group.
- Polymorphism apoliproproteina of APOE gene. This is the most common form of mutation, which results in the disease in 30-55% of cases.
But, despite the fact that the genetic factor is present from birth, as genes are present in the body from the time of birth, the disease does not occur all at once, in adolescence or at the age of 25. This gives the reason to conclude that the genetic factors are not enough for development of Alzheimer's disease. It is obvious that there must be a complex effect on the body, where one of the leading roles are played by the aging process.
Thus, aging process is able to disturb the process of self- regeneration of the body and cells that can ultimately lead to the development of Alzheimer's disease.
Genetic testing for predisposition to Alzheimer's disease
Genetic testing helps to make a prediction, whether a person has a tendency to suffer from Alzheimer's disease or not. In other words, by means of genetic testing, it is possible to determine the presence of ApoE4 gene that indicates a propensity for the disease. But we should remember that today there is no way to test susceptibility to rare spontaneous form of the disease. Thus, doctors do not recommend to pass this analysis for the vast majority of people who had the cases of the disease among their relatives, since the presence of the gene may indicate only a tendency, but not determine whether the disease will develop in the future or not.
Nevertheless, the compliance with preventive measures, consisting of proper nutrition, healthy lifestyle, harmonious combination of physical activity and rest is recommended to all the people who have reached old age.
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